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Article

Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2000

Schaefer M L, Wong S T, Wozniak D F, Muglia L M, Liauw J A, Zhuo M, Nardi A, Hartman R E, Vogt S K, Luedke C E, Storm D R, Muglia L J

Abstract excerpt

Stress results in alterations in behavior and physiology that can be either adaptive or maladaptive. To define the molecular pathways involved in the response to stress further, we generated mice deficient (KO) in the calcium-stimulated adenylyl cyclase type VIII (AC8) by homologous recombination in embryonic stem cells. AC8 KO mice demonstrate a compromise in calcium-stimulated AC activity in the hippocampus,...

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PMID: 10864938
PMCID: PMC6772287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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