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Article

Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease.

BMC medical genetics - 5 Sept 2007

Cavallari Ugo, Trabetti Elisabetta, Malerba Giovanni, Biscuola Michele, Girelli Domenico, Olivieri Oliviero, Martinelli Nicola, Angiolillo Dominick J, Corrocher Roberto, Pignatti Pier Franco

Abstract excerpt

BACKGROUND: The platelet P2Y12 receptor plays a key role in platelet activation. The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. No data are available on its association with coronary artery disease (CAD). METHODS: The H2 haplotype of the P2RY12 was...

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Identifiers

PMID: 17803810
DOI: 10.1186/1471-2350-8-59
PMCID: PMC2048504

Genes

CAD

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Source receipt: pubmed, retrieved 7 Sept 2026.

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