Article
Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir.
BMC biology - 11 Jul 2018
Roychoudhury Pavitra, De Silva Feelixge Harshana, Reeves Daniel, Mayer Bryan T, Stone Daniel, Schiffer Joshua T, Jerome Keith R
Abstract excerpt
BACKGROUND: RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies to date have focused on molecular clones with ideal target site recognition and do not account for target site variability observed within and between patients. For clinical success and broad...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.