Article
Human genetic disorders and knockout mice deficient in glycosaminoglycan.
BioMed research international - 1 Jan 2014
Mizumoto Shuji, Yamada Shuhei, Sugahara Kazuyuki
Abstract excerpt
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective monosaccharides by various glycosyltransferases and maturated by epimerases and sulfotransferases. The structural diversity of GAG polysaccharides, including their sulfation patterns and sequential arrangements, is essential for a wide range of biological activities such as cell signaling, cell proliferation, tissue...
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