Article

Decreased fucosylation impacts epithelial integrity and increases risk for COPD

2023-11-02

Abstract excerpt

COPD causes significant morbidity and mortality worldwide. Epithelial damage is fundamental to disease pathogenesis, although the mechanisms driving disease remain undefined. Published evidence from a COPD cohort (SPIROMICS) and confirmed in a second cohort (COPDgene) demonstrate a polymorphism in Fucosyltransferese-2 (FUT2) is a trans-pQTL for E-cadherin, which is critical in COPD pathogenesis. We found by MALDI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83067c2a-dfb0-5a37-876c-1dbe4f1fc86f
DOI: 10.1101/2023.10.31.564805

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decreased fucosylation impacts epithelial integrity and increases risk for COPDDOI 10.1101/2023.10.31.564805Read

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.Semantic proximity Read

Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus ObstructionSemantic proximity Read

Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced EmphysemaSemantic proximity Read

Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema.Semantic proximity Read

Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).Semantic proximity Read

Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori bindingSemantic proximity Read

Epithelial glycosylation in gut homeostasis and inflammation.Semantic proximity Read

Biological functions of fucose in mammals.Semantic proximity Read

FUT2-mediated α1,2-fucosylation in inflammatory bowel disease: mechanisms and translational potential.Semantic proximity Read

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.Semantic proximity Read

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infectionSemantic proximity Read

Genetic Diseases of Fucosylation: Insights from Model OrganismsSemantic proximity Read