Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma.

Neoplasia (New York, N.Y.) - 1 Nov 2006

Armstrong Michael B, Bian Xin, Liu Yihong, Subramanian Chitra, Ratanaproeksa Anthony B, Shao Feng, Yu Victor C, Kwok Roland P S, Opipari Anthony W, Castle Valerie P

Abstract excerpt

Neuroblastic (N) type neuroblastoma (NB) is the predominant cell type in NB tumors. Previously, we determined that activated nuclear factor kappaB (NF-kappaB) is required for doxorubicin and etoposide to kill N-type NB cells. This study was undertaken to determine how NF-kappaB is activated by these agents. The results show that p53 protein levels increase within 15 to 30 minutes of treatment. This increase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MAP Kinase Kinase 1
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Doxorubicin

Share to Etoposide

Share to Neuroblastoma

Share to NF-kappa B

Share to Ribosomal Protein S6 Kinases, 90-kDa

Source

Identifiers

PMID: 17132229
DOI: 10.1593/neo.06574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma.PMID 17132229Read ↗

NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells.Semantic proximity Read ↗

Role of NF-kappaB in p53-mediated programmed cell death.Semantic proximity Read ↗

Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA DamageSemantic proximity Read ↗

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancerSemantic proximity Read ↗

Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells.Semantic proximity Read ↗

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1Semantic proximity Read ↗

Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.Semantic proximity Read ↗

Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.Semantic proximity Read ↗

DNA‐damaging drug‐induced apoptosis sensitized by <i>N‐myc</i> in neuroblastoma cellsSemantic proximity Read ↗

Inhibition of the Canonical IKK/NF&kappa;B Pathway Sensitizes Human Cancer Cells to DoxorubicinSemantic proximity Read ↗

Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells.Semantic proximity Read ↗

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.