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Article

NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells.

The Journal of biological chemistry - 28 Dec 2001

Bian X, McAllister-Lucas L M, Shao F, Schumacher K R, Feng Z, Porter A G, Castle V P, Opipari A W

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor of childhood. N-type neuroblastoma cells (represented by SH-SY5Y and IMR32 cell lines) are characterized by a neuronal phenotype. N-type cell lines are generally N-myc amplified, express the anti-apoptotic protein Bcl-2, and do not express caspase-8. The present study was designed to determine the mechanism by which N-type cells die in response to specific...

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PMID: 11679590
DOI: 10.1074/jbc.M108674200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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