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Article

Inhibition of the Canonical IKK/NF&kappa;B Pathway Sensitizes Human Cancer Cells to Doxorubicin

15 Sept 2007

Abstract excerpt

The NF kappa B family is composed by five subunits (p65/RelA, c-Rel, RelB, p105-p50/NF kappa B(1), p100-p52/NF kappa B(2)) and controls the expression of many genes that participate in cell cycle, apoptosis, and other key cellular processes. In a canonical pathway, NF kappa B activation depends on the IKK complex activity, which is formed by three subunits (IKKalpha and IKKbeta and IKKgamma/NEMO). There is an...

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PMID: 17890907
DOI: 10.4161/cc.6.18.4721

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