Article
Role of NF-kappaB in p53-mediated programmed cell death.
Nature - 20 Apr 2000
Ryan K M, Ernst M K, Rice N R, Vousden K H
Abstract excerpt
The tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and apoptosis, and most cancers have either mutation within the p53 gene or defects in the ability to induce p53. Activation or re-introduction of p53 induces apoptosis in many tumour cells and may provide effective cancer therapy. One of the key proteins that modulates the apoptotic response is NF-kappaB, a transcription...
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