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Article

Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells.

Biochemical and biophysical research communications - 11 Feb 2011

Wu Chun Chi, Yu Chang-Tze Ricky, Chang Gee-Chen, Lai Jin-Mei, Hsu Shih-Lan

Abstract excerpt

Mutations of the p53 tumor suppressor gene are the most common mutations found in human tumors. There is increasing evidence that suggests that p53 status is a determinant of chemosensitivity of tumor cells. We have previously demonstrated that p53 is a crucial regulator in mediating gefitinib-induced cell death, which upregulates apoptosis-related molecules. However, the mechanism of p53 involvement in cellular...

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Identifiers

PMID: 21216229
DOI: 10.1016/j.bbrc.2011.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells.PMID 21216229Read ↗

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