Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.

FEBS letters - 11 Dec 2006

Liu Aihua, Oliver-Krasinski Jennifer, Stoffers Doris A

Abstract excerpt

PCIF1 is a TRAF and POZ domain containing nuclear factor that interacts with and inhibits transactivation of pancreatic homeodomain transcription factor PDX-1. Here, we demonstrate interaction of endogenous PDX-1 and PCIF1 in MIN6 insulinoma cells. Within PCIF1, the TRAF and POZ domains are both required for physical and functional interaction with the C-terminus of PDX-1, whereas the C-terminal domain of PCIF1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Conserved Sequence
Share to Glutamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Pancreas

Share to Transcriptional Activation

Share to Ubiquitin-Protein Ligase Complexes

Share to Zebrafish

Source

Identifiers

PMID: 17126328
DOI: 10.1016/j.febslet.2006.11.021

Genes

PCIF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.PMID 17126328Read ↗

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional ActivitySemantic proximity Read ↗

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceSemantic proximity Read ↗

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.Semantic proximity Read ↗

Biophysical insights into glucose-dependent transcriptional regulation by PDX1Semantic proximity Read ↗

Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)Semantic proximity Read ↗

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300.Semantic proximity Read ↗

TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growthSemantic proximity Read ↗

Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.Semantic proximity Read ↗

Involvement of PDX-1 in activation of human insulin gene transcriptionSemantic proximity Read ↗

MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β CellsSemantic proximity Read ↗

Defining unique structural features in the MAFA and MAFB transcription factors that control <i>Insulin</i> gene activitySemantic proximity Read ↗

Role of the POZ Zinc Finger Transcription Factor FBI-1 in Human and Murine AdipogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.