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Article

TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth

1 Apr 2000

Abstract excerpt

The control of epithelial cell proliferation, differentiation, and apoptosis requires a balance between signaling and transcriptional regulation. Recent developments in pancreatic cell research have revealed that transforming growth factor-beta (TGF-beta) signaling is important for the regulation of each of these phenomena. More importantly, perturbations in this pathway are associated with pancreatic cancer. A...

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PMID: 10762604
DOI: 10.1152/ajpgi.2000.278.4.g513

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