Article
Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.
Journal of neurochemistry - 1 Oct 2016
Villar-Piqué Anna, Lopes da Fonseca Tomás, Outeiro Tiago Fleming
Abstract excerpt
Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders characterized by the misfolding and accumulation of alpha-synuclein aggregates that are commonly known as synucleinopathies. Clinically, synucleinopathies are heterogeneous, reflecting the somewhat selective neuronal vulnerability characteristic of each disease. The precise molecular underpinnings of synucleinopathies remain...
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