Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6.

Cell - 19 Sept 2003

Chen Elizabeth H, Pryce Brian A, Tzeng Jarvis A, Gonzalez Guillermo A, Olson Eric N

Abstract excerpt

Myoblast fusion is essential for the formation and regeneration of skeletal muscle. In a genetic screen for regulators of muscle development in Drosophila, we discovered a gene encoding a guanine nucleotide exchange factor, called loner, which is required for myoblast fusion. Loner localizes to subcellular sites of fusion and acts downstream of cell surface fusion receptors by recruiting the small GTPase ARF6 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 6
Share to ADP-Ribosylation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Fusion

Share to Embryo, Nonmammalian

Share to Guanine Nucleotide Exchange Factors

Share to Muscle Fibers, Skeletal

Share to Myoblasts

Share to rac GTP-Binding Proteins

Source

Identifiers

PMID: 14505574
DOI: 10.1016/s0092-8674(03)00720-7

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6.PMID 14505574Read ↗

The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.Semantic proximity Read ↗

The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.Semantic proximity Read ↗

Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded.Semantic proximity Read ↗

Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila.Semantic proximity Read ↗

SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.Semantic proximity Read ↗

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.Semantic proximity Read ↗

Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo.Semantic proximity Read ↗

Drosophila dumbfounded: a myoblast attractant essential for fusion.Semantic proximity Read ↗

PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.Semantic proximity Read ↗

In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.Semantic proximity Read ↗

kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila.Semantic proximity Read ↗

The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.