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Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

6 Feb 2017

Abstract excerpt

Coronaviruses and arteriviruses are distantly related human and animal pathogens that belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus-stranded RNA genome, the production of subgenomic mRNAs and the conservation of a specific array of replicase domains, including key RNA-synthesizing enzymes. Coronaviruses (26-34 kilobases) have the largest known RNA genomes and their...

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PMID: 28174054
DOI: 10.1016/j.virusres.2017.01.023

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