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Article

Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis

7 Aug 2006

Abstract excerpt

Norovirus (NV) 3D(pol) is a non-structural protein predicted to play an essential role in the replication of the NV genome. In this study, the characteristics of NV 3D(pol) activity and initiation of RNA synthesis have been examined in vitro. Recombinant NV 3D(pol), as well as a 3D(pol) active-site mutant were expressed in Escherichia coli and purified. NV 3D(pol) was able to synthesize RNA in vitro and displayed...

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PMID: 16894201
DOI: 10.1099/vir.0.81802-0

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