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Article

Mutations which decouple the proton pump of the cytochrome c oxidase from Rhodobacter sphaeroides perturb the environment of glutamate 286.

FEBS letters - 21 Aug 2006

Vakkasoglu Ahmet S, Morgan Joel E, Han Dan, Pawate Ashtamurthy S, Gennis Robert B

Abstract excerpt

Mutants that decouple the proton pump of cytochrome c oxidase from Rhodobacter sphaeroides are postulated to do so by increasing the pK(a) of glutamate 286, which is 20 Angstrom away. The possibility that a conformational change near E286 is induced by the decoupling mutations (N139D and N207D) was investigated by FTIR difference spectroscopy. In both decoupled mutants, the reduced-minus-oxidized FTIR difference...

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Identifiers

PMID: 16890226
DOI: 10.1016/j.febslet.2006.07.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations which decouple the proton pump of the cytochrome c oxidase from Rhodobacter sphaeroides perturb the environment of glutamate 286.PMID 16890226Read ↗

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