Article
Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS.
Journal of bacteriology - 1 Feb 2007
Bai Haibo, Lu A-Lien
Abstract excerpt
Escherichia coli MutY and MutS increase replication fidelity by removing adenines that were misincorporated opposite 7,8-dihydro-8-oxo-deoxyguanines (8-oxoG), G, or C. MutY DNA glycosylase removes adenines from these mismatches through a short-patch base excision repair pathway and thus prevents G:C-to-T:A and A:T-to-G:C mutations. MutS binds to the mismatches and initiates the long-patch mismatch repair on...
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