Article
Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Michaels M L, Cruz C, Grollman A P, Miller J H
Abstract excerpt
It has been previously shown both in vivo and in vitro that DNA synthesis past an oxidatively damaged form of guanine, 7,8-dihydro-8-oxoguanine (8-oxoG), can result in the misincorporation of adenine (A) opposite the 8-oxodG. In this study we show that MutY glycosylase is active on a site-specifi...
Topics
- Bacterial Proteins
- Base Composition
- Base Sequence
- DNA Damage
- DNA Glycosylases
- DNA Repair
- DNA Replication
- DNA-Formamidopyrimidine Glycosylase
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genetic Complementation Test
- Guanine
- Models, Genetic
- Molecular Sequence Data
- Mutation
- N-Glycosyl Hydrolases
- Oligodeoxyribonucleotides