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Article

Crystal Structure of Vat(D): An Acetyltransferase That Inactivates Streptogramin Group A Antibiotics,

25 Jan 2002

Abstract excerpt

The streptogramin class of antibiotics act to inhibit bacterial protein synthesis, and their semisynthetic derivatives, such as dalfopristin-quinupristin (Synercid), are used to treat serious or life-threatening infections due to multiply antibiotic resistant bacteria. Acquired resistance of the nosocomial pathogen Enterococcus faecium to the group A component of natural and semisynthetic streptogramin mixtures...

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PMID: 11841212
DOI: 10.1021/bi011991b

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