Structural and functional analysis of the protein products derived from mutant fur alleles in an endoprotease-deficient Chinese hamster ovary cell strain.

doi:10.1023/b:scam.0000007111.46513.70

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Article

Structural and functional analysis of the protein products derived from mutant fur alleles in an endoprotease-deficient Chinese hamster ovary cell strain.

Somatic cell and molecular genetics - 1 Mar 1998

Sucic J F, Spence M J, Moehring T J

Abstract excerpt

The fur gene encodes the endoprotease, furin. We recently demonstrated mutations in both fur alleles in the mutant Chinese hamster ovary (CHO)-K1 strain, RPE.40, and hypothesized that these mutations were responsible for the endoprotease-deficient phenotype of these cells. We now present the stru...

Topics

Alleles
Animals
CHO Cells
Cricetinae
Cysteine
Furin
Glycosylation
Mutation
Protein Processing, Post-Translational
RNA Splicing
Subtilisins
Transfection
Tyrosine

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