Article
Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.
Clinical immunology (Orlando, Fla.) - 1 Mar 2007
Veldman Christian, Eming Rüdiger, Wolff-Franke Sonja, Sonderstrup Grete, Kwok William W, Hertl Michael
Abstract excerpt
In the present study, we developed a HLA class II tetramer-based detection system utilizing DRB1*0402 tetramers loaded with recently identified immunodominant peptides of desmoglein 3 (Dsg3), the major autoantigen of pemphigus vulgaris (PV). Initial experiments demonstrated staining of a Dsg3-reactive T cell hybridoma which was derived from HLA-DR0402-transgenic mice with loaded PE-labeled DRbeta1*0402 tetramers....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.