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Article

Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris.

The Journal of dermatology - 1 Nov 1999

Hertl M, Riechers R

Abstract excerpt

Pemphigus vulgaris (PV) is a classical example of an antibody-mediated autoimmune disease of the skin. Direct evidence exists that autoantibodies against the desmosomal adhesion molecule, desmoglein 3 (Dsg3), are critical in the pathogenesis of this disease. The transfer of serum IgG antibodies reactive with Dsg3 into newborn mice induces a bullous skin disease resembling PV. Autoreactive T cell responses to Dsg3...

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Identifiers

PMID: 10635617
DOI: 10.1111/j.1346-8138.1999.tb02086.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris.PMID 10635617Read ↗

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Immune response in pemphigus and beyond: progresses and emerging concepts.Semantic proximity Read ↗

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Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.Semantic proximity Read ↗

Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigusSemantic proximity Read ↗

Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.Semantic proximity Read ↗

Novel System Evaluating In Vivo Pathogenicity of Desmoglein 3-Reactive T Cell Clones Using Murine Pemphigus VulgarisSemantic proximity Read ↗

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Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interfaceSemantic proximity Read ↗

IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.Semantic proximity Read ↗

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.Semantic proximity Read ↗

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