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Deregulated phenotype of autoreactive Th17 and Treg clone cells in pemphigus vulgaris after in-vitro treatment with desmoglein antigen (Dsg-3).

Immunobiology - 1 Mar 2023

Ansari Mohammad Ahmad, Singh Praveen Kumar, Dar Sajad Ahmad, Rai Gargi, Akhter Naseem, Pandhi Deepika, Gaurav Vishal, Bhattacharya Sambit Nath, Banerjee Basu Dev, Ahmad Abrar, Das Shukla

Abstract excerpt

The loss of balance between regulatory T (Treg) and T helper 17 (Th17) causes loss of tolerance against desmoglein (Dsg)-3 leading to pemphigus vulgaris (PV), an autoimmune bullous skin disorder associated with autoantibodies against Dsg-3. We aimed to elucidate the complex relationship of Th17 and Treg cells, their molecules, and the underlying mechanism in the development of PV disease. Using cytokine secretion...

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PMID: 36689824
DOI: 10.1016/j.imbio.2023.152340

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