Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.

doi:10.1002/jcp.21096

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Article

Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.

Journal of cellular physiology - 1 Sept 2007

Bouchard Véronique, Demers Marie-Josée, Thibodeau Sonya, Laquerre Vincent, Fujita Naoya, Tsuruo Takashi, Beaulieu Jean-François, Gauthier Rémy, Vézina Anne, Villeneuve Lisabeth, Vachon Pierre H

Abstract excerpt

Human intestinal epithelial cell survival and anoikis are distinctively regulated according to the state of differentiation. In the present study, we analyzed the roles of focal adhesion kinase (Fak)/Src signaling to the PI3-K/Akt-1 and mitogen-activated protein kinase (MEK)/extracellular regulated kinases (Erk) pathways, within the context of such differentiation-state distinctions. Anoikis was induced by...

Topics

Anoikis
Caco-2 Cells
Cell Adhesion
Cell Differentiation
Cell Survival
Enterocytes
Extracellular Signal-Regulated MAP Kinases
Focal Adhesion Kinase 1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Integrin beta1

Intestinal Mucosa

Mitogen-Activated Protein Kinase 1

Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinase Kinases

Mutation

Phosphatidylinositol 3-Kinases

Phosphoinositide-3 Kinase Inhibitors

Protein Kinase Inhibitors

Source

Open in PubMed

Identifiers

PMID: 17443665
DOI: 10.1002/jcp.21096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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