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Article

In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2003

Brunner Michael, Kodirov Sodikdjon A, Mitchell Gary F, Buckett Peter D, Shibata Katsushi, Folco Eduardo J, Baker Linda, Salama Guy, Chan Danny P, Zhou Jun, Koren Gideon

Abstract excerpt

Mutations in cardiac voltage-gated K+ channels cause long QT syndrome (LQTS) and sudden death. We created a transgenic mouse with a long QT phenotype (Kv1DN) by overexpression of a truncated K+ channel in the heart and investigated whether the dominant negative effect of the transgene would be overcome by the direct injection of adenoviral vectors expressing wild-type Kv1.5 (AV-Kv1.5) into the myocardium. End...

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Identifiers

PMID: 12793978
DOI: 10.1152/ajpheart.00971.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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