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Article

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.

Human molecular genetics - 1 Dec 1998

Petris M J, Camakaris J, Greenough M, LaFontaine S, Mercer J F

Abstract excerpt

The human X-linked recessive disorder of copper metabolism, Menkes disease, is caused by a defect in the MNK ( ATP7A ) gene which encodes a transmembrane copper-transporting P-type ATPase (MNK). MNK is an important component of the mammalian copper transport pathway, and previous studies in cultured cells have localized MNK to the final compartment of the Golgi apparatus, the trans -Golgi network (TGN). At this...

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Identifiers

PMID: 9817923
DOI: 10.1093/hmg/7.13.2063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.PMID 9817923Read ↗

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Semantic proximity Read ↗

Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A; MNK). Endocytosis of the Menkes protein.Semantic proximity Read ↗

Characterization of the Menkes protein copper-binding domains and their role in copper-induced protein relocalization.Semantic proximity Read ↗

The Menkes copper transporter is required for the activation of tyrosinase.Semantic proximity Read ↗

Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network.Semantic proximity Read ↗

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.Semantic proximity Read ↗

Menkes disease.Semantic proximity Read ↗

A conditional mutation affecting localization of the Menkes disease copper ATPase. Suppression by copper supplementation.Semantic proximity Read ↗

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.Semantic proximity Read ↗

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.Semantic proximity Read ↗

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.Semantic proximity Read ↗

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.Semantic proximity Read ↗

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