Article
A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.
Human molecular genetics - 1 Dec 1998
Petris M J, Camakaris J, Greenough M, LaFontaine S, Mercer J F
Abstract excerpt
The human X-linked recessive disorder of copper metabolism, Menkes disease, is caused by a defect in the MNK ( ATP7A ) gene which encodes a transmembrane copper-transporting P-type ATPase (MNK). MNK is an important component of the mammalian copper transport pathway, and previous studies in cultu...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- CHO Cells
- Carrier Proteins
- Cation Transport Proteins
- Cloning, Molecular
- Copper
- Copper-Transporting ATPases
- Cricetinae
- Golgi Apparatus
- Leucine
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Plasmids
- Recombinant Fusion Proteins