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Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters

1 Jul 1997

Abstract excerpt

Menkes disease and Wilson disease are human disorders of copper transport caused by mutations in distinct genes encoding similar copper-transporting P-type ATPases. These genes are expressed in different adult tissues in patterns reflecting disease manifestations. The mouse homologues for the Menkes (MNK) and Wilson (WND) disease genes are the mottled (Atp7a) and toxic milk (Atp7b) genes, respectively. Using RNA...

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PMID: 9215673
DOI: 10.1093/hmg/6.7.1043

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Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transportersPMID 9215673Read ↗

The toxic milk mouse is a murine model of Wilson disease.Semantic proximity Read ↗

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase.Semantic proximity Read ↗

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The mottled gene is the mouse homologue of the Menkes disease gene.Semantic proximity Read ↗

Alterations in the expression of the Atp7a gene in the early postnatal development of the mosaic mutant mice (Atp7a mo-ms) - An animal model for Menkes disease.Semantic proximity Read ↗

Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease.Semantic proximity Read ↗

Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.Semantic proximity Read ↗

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Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease.Semantic proximity Read ↗

Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease proteinSemantic proximity Read ↗

Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant.Semantic proximity Read ↗

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