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Article

Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2006

Senatorov Vladimir, Malyukova Irina, Fariss Robert, Wawrousek Eric F, Swaminathan Srividya, Sharan Shyam K, Tomarev Stanislav

Abstract excerpt

We developed a genetic mouse model of open-angle glaucoma by expression of mutated mouse myocilin (Myoc) in transgenic (Tg) mice. The Tyr423His point mutation, corresponding to the severe glaucoma-causing Tyr437His mutation in the human MYOC gene, was introduced into bacterial artificial chromosome DNA encoding the full-length mouse Myoc gene and long flanking regions. Both wild-type (Wt) and Tg animals expressed...

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Source

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Identifiers

PMID: 17108164
DOI: 10.1523/JNEUROSCI.3020-06.2006
PMCID: PMC6674879

Genes

MYOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.PMID 17108164Read ↗

Transgenic Mice Expressing the Tyr437His Mutant of Human Myocilin Protein Develop GlaucomaSemantic proximity Read ↗

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Overexpression and Properties of Wild-Type and Tyr437His Mutated Myocilin in the Eyes of Transgenic MiceSemantic proximity Read ↗

Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis.Semantic proximity Read ↗

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Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucomaSemantic proximity Read ↗

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