Article
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
Molecular and cellular biology - 1 Nov 2006
Gould Douglas B, Reedy Mark, Wilson Lawriston A, Smith Richard S, Johnson Randy L, John Simon W M
Abstract excerpt
Glaucoma is a leading cause of blindness, affecting over 70 million people worldwide. Vision loss is the result of death of the retinal ganglion cells. The best-known risk factor for glaucoma is an elevated intraocular pressure (IOP); however, factors leading to IOP elevation are poorly understood. Mutations in the MYOC gene are an important cause of open-angle glaucoma. Over 70 MYOC mutations have been...
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