Article
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.
The Journal of clinical investigation - 1 Sept 2011
Zode Gulab S, Kuehn Markus H, Nishimura Darryl Y, Searby Charles C, Mohan Kabhilan, Grozdanic Sinisa D, Bugge Kevin, Anderson Michael G, Clark Abbot F, Stone Edwin M, Sheffield Val C
Abstract excerpt
Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report the development of a transgenic mouse model of POAG caused by the Y437H MYOC mutation; the mice are referred to herein as Tg-MYOC(Y437H) mice. Analysis of adult Tg-MYOC(Y437H) mice, which we showed express human MYOC...
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