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Article

Mutated mouse and human myocilins have similar properties and do not block general secretory pathway.

Investigative ophthalmology & visual science - 1 Jan 2006

Malyukova Irina, Lee Hee-Sheung, Fariss Robert N, Tomarev Stanislav I

Abstract excerpt

PURPOSE: The present study compared properties of wild-type and mutated mouse and human myocilin (Myoc) proteins as a prerequisite for development of a mouse model of glaucoma. METHODS: cDNA encoding full-length mouse Myoc was cloned into the p3XFLAG-CMV-14 vector. Tyr423His and Ile463Ser mutations were introduced into the mouse Myoc protein by in vitro mutagenesis. Intracellular localization and secretion of...

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Identifiers

PMID: 16384964
DOI: 10.1167/iovs.05-0220

Genes

MYOC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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