Article

Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

2023-12-19

Abstract excerpt

Mutations in myocilin ( MYOC ) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplasmic reticulum (ER) leading to ER stress and trabecular meshwork (TM) cell death. Therefore, knocking out myocilin at the genome level is an ideal strategy to permanently cure...

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Literature Corpus work: e55545e9-42f1-5457-8d17-b3c108cf893c
DOI: 10.21203/rs.3.rs-3740880/v1

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