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Article

Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.

American journal of physiology. Cell physiology - 1 Apr 2007

Wang Bin, Schneider Scott N, Dragin Nadine, Girijashanker Kuppuswami, Dalton Timothy P, He Lei, Miller Marian L, Stringer Keith F, Soleimani Manoocher, Richardson Douglas D, Nebert Daniel W

Abstract excerpt

Resistance to cadmium (Cd)-induced testicular necrosis is an autosomal recessive trait defined as the Cdm locus. Using positional cloning, we previously identified the Slc39a8 (encoding an apical-surface ZIP8 transporter protein) as the gene most likely responsible for the phenotype. In situ hybridization revealed that endothelial cells of the testis vasculature express high ZIP8 levels in two sensitive inbred...

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Identifiers

PMID: 17108009
DOI: 10.1152/ajpcell.00409.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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