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Article

Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.

International journal of molecular sciences - 19 Feb 2021

Lu Xing, Long Yong, Li Xixi, Zhang Lang, Li Qing, Wen Hua, Zhong Shan, Cui Zongbin

Abstract excerpt

Lead (Pb) is one of the major heavy metals that are toxic to vertebrates and usually considered as environmental pollutants. ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 and its orthologs function in the detoxification and excretion of toxic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33669601
DOI: 10.3390/ijms22042054
PMCID: PMC7923114

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