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Article

Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.

American journal of physiology. Renal physiology - 1 Mar 2007

Sneddon W Bruce, Yang Yanmei, Ba Jianming, Harinstein Lisa M, Friedman Peter A

Abstract excerpt

The PTH receptor (PTH1R) activates multiple signaling pathways, including extracellular signal-regulated kinases 1 and 2 (ERK1/2). The role of epidermal growth factor receptor (EGFR) transactivation in ERK1/2 activation by PTH in distal kidney cells, a primary site of PTH action, was characterized. ERK1/2 phosphorylation was stimulated by PTH and blocked by the EGFR inhibitor, AG1478. Upon PTH stimulation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17107942
DOI: 10.1152/ajprenal.00288.2006

Genes

PTH
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.PMID 17107942Read ↗

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Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Semantic proximity Read ↗

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Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling.Semantic proximity Read ↗

Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.Semantic proximity Read ↗

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A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.Semantic proximity Read ↗

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors.Semantic proximity Read ↗

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