Article
Proteomics of p53 in diagnostics and therapy of acute myeloid leukemia.
Current pharmaceutical biotechnology - 1 Jun 2006
Anensen Nina, Haaland Ingvild, D'Santos Clive, Van Belle Werner, Gjertsen Bjørn Tore
Abstract excerpt
The anti-oncogene TP53 is frequently mutated in human cancer, but in hematological malignancies this is a rare feature. In acute myeloid leukemia (AML) more than 90% of the patients comprise wild type TP53 in their cancer cells, but if TP53 is mutated or deleted the disease is often found to be c...
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