Article
Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology.
PloS one - 1 Jan 2011
Proepper Christian, Steinestel Konrad, Schmeisser Michael J, Heinrich Jutta, Steinestel Julie, Bockmann Juergen, Liebau Stefan, Boeckers Tobias M
Abstract excerpt
BACKGROUND: Abelson-interacting protein 1 (Abi-1) plays an important role for dendritic branching and synapse formation in the central nervous system. It is localized at the postsynaptic density (PSD) and rapidly translocates to the nucleus upon synaptic stimulation. At PSDs Abi-1 is in a complex with several other proteins including WASP/WAVE or cortactin thereby regulating the actin cytoskeleton via the Arp 2/3...
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