Article
Deleterious pleiotropic effects of the atypical aldehyde dehydrogenase 2 (ALDH2) allele: comment on Luo et al., 2005.
Biochemical genetics - 1 Oct 2006
Sinclair David
Abstract excerpt
Luo [Biochem. Genet. 43:223-227] concluded, "The mutation ALDH2(() 487Lys allele is not deleterious but is of great benefit to human health." This statement is easily subject to misinterpretation and needs to be clarified. Their results actually show there is a pleiotropic effect associated with the mutation ALDH2(() 487Lys allele that is as deleterious as the risk of alcoholism for which it offers protection,...
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