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Article

An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson's disease.

BMC geriatrics - 16 May 2022

Fan Hui-Hui, Zheng Jing, Huang Xiao-Ya, Wu Ke-Yun, Cui Lei, Dong Hao-Jia, Wang Zhen, Zhang Xiong, Zhu Jian-Hong

Abstract excerpt

BACKGROUND: Aldehyde dehydrogenase 1 (encoded by ALDH1A1) has been shown to protect against Parkinson's disease (PD) by reducing toxic metabolites of dopamine. We herein revealed an antisense Alu element insertion/deletion polymorphism in intron 4 of ALDH1A1, and hypothesized that it might play a role in PD. METHODS: A Han Chinese cohort comprising 488 PD patients and 515 controls was recruited to validate the...

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Identifiers

PMID: 35578164
DOI: 10.1186/s12877-022-03132-1
PMCID: PMC9109383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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