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Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis

9 Apr 2021

Abstract excerpt

Prolyl 3-hydroxylase 2 (P3H2) catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Its activity has never been directly associated to angiogenesis. Here, we identified P3H2 gene through a deep-sequencing transcriptome analysis of human umbilical vein endothelial cells (HUVECs) stimulated with vascular endothelial growth factor A (VEGF-A). Differently from many previous...

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PMID: 33918807
DOI: 10.3390/ijms22083896

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