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Article

Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.

Antimicrobial agents and chemotherapy - 1 Feb 2007

Murakami Eisuke, Bao Haiying, Ramesh Mangala, McBrayer Tamara R, Whitaker Tony, Micolochick Steuer Holly M, Schinazi Raymond F, Stuyver Lieven J, Obikhod Aleksandr, Otto Michael J, Furman Phillip A

Abstract excerpt

Beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) is a potent specific inhibitor of hepatitis C virus (HCV) RNA synthesis in Huh-7 replicon cells. To inhibit the HCV NS5B RNA polymerase, PSI-6130 must be phosphorylated to the 5'-triphosphate form. The phosphorylation of PSI-6130 and inhibition of HCV NS5B were investigated. The phosphorylation of PSI-6130 by recombinant human 2'-deoxycytidine kinase (dCK)...

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Identifiers

PMID: 17101674
DOI: 10.1128/AAC.00400-06
PMCID: PMC1797721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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