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Article

Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.

The Journal of biological chemistry - 14 Nov 2008

Lima Christopher D, Reverter David

Abstract excerpt

Small ubiquitin-like modifier (SUMO) proteases regulate the abundance and lifetime of SUMO-conjugated substrates by antagonizing reactions catalyzed by SUMO-conjugating enzymes. Six SUMO proteases constitute the human SENP/ULP protease family (SENP1-3 and SENP5-7). SENP6 and SENP7 include the most divergent class of SUMO proteases, which also includes the yeast enzyme ULP2. We present the crystal structure of the...

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Topics

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Share to Catalytic Domain
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Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to SUMO-1 Protein

Source

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Identifiers

PMID: 18799455
DOI: 10.1074/jbc.M805655200
PMCID: PMC2581585

Genes

SENP7
SENP6
SUMO2
SUMO3
SENP2
SENP1
SENP5
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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