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Article

Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.

The Journal of biological chemistry - 16 Jun 2017

Singh Rahul, Jamdar Sahayog N, Goyal Venuka Durani, Kumar Ashwani, Ghosh Biplab, Makde Ravindra D

Abstract excerpt

The human aminopeptidase XPNPEP3 is associated with cystic kidney disease and TNF-TNFR2 cellular signaling. Its yeast and plant homolog Icp55 processes several imported mitochondrial matrix proteins leading to their stabilization. However, the molecular basis for the diverse roles of these enzymes in the cell is unknown. Here, we report the crystal structure of human XPNPEP3 with bound apstatin product at 1.65 Å...

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Identifiers

PMID: 28476889
DOI: 10.1074/jbc.M117.783357
PMCID: PMC5473211

Genes

XPNPEP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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