Article
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
Nature - 20 Mar 2003
Walden Helen, Podgorski Michael S, Schulman Brenda A
Abstract excerpt
Post-translational modification by ubiquitin-like proteins (Ublps) is an essential cellular regulatory mechanism. The Ublp NEDD8 regulates cell division, signalling and embryogenesis. Ublps are conjugated to their targets by the sequential action of E1, E2 and often E3 enzymes. Each Ublp has a dedicated E1, or activating enzyme, that initiates its conjugation cascade. First, E1 associates with the Ublp and...
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