TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium.

doi:10.1002/ijc.22310

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Article

TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium.

International journal of cancer - 1 Feb 2007

Booth Brian W, Jhappan Chamelli, Merlino Glenn, Smith Gilbert H

Abstract excerpt

Growth factors and hormones are responsible for development of the mammary gland and can contribute to mammary carcinogenesis. The transforming growth factors (TGF) alpha and beta1 demonstrate opposing effects on the mammary epithelium. TGFalpha is a mitogen and survival factor for mammary secretory cells and is often upregulated in cancer, while TGFbeta1 may act as a growth suppressor and has been shown to...

Topics

Animals
Apoptosis
Cell Survival
Epithelium
Female
Genotype
Humans
Immunohistochemistry
Male
Mammary Glands, Animal
Mammary Neoplasms, Experimental
Mice
Mice, Inbred Strains
Mice, Transgenic
Phenotype
Precancerous Conditions
Proliferating Cell Nuclear Antigen
Transforming Growth Factor alpha

Source

Open in PubMed

Identifiers

PMID: 17096338
DOI: 10.1002/ijc.22310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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