Article
The prevalence of reduced zidovudine susceptibility in zidovudine-naive, antiretroviral-experienced HIV-1-infected patients.
HIV medicine - 1 Oct 2003
Gilleece Y, Torti C, Mandalia S, Gazzard B G, Pillay D, Pozniak A L
Abstract excerpt
OBJECTIVES: There is increasing in vitro and in vivo evidence that reduced zidovudine (ZDV) susceptibility is generated by the selective pressure conferred by other nucleoside reverse transcriptase inhibitors (NRTIs). However, the degree to which this occurs in clinical practice remains unclear. We assessed phenotypic and genotypic resistance in ZDV-naive patients with virological failure on stavudine...
Topics
- Anti-HIV Agents
- Drug Resistance, Multiple
- Drug Resistance, Viral
- Drug Therapy, Combination
- HIV Infections
- Humans
- Mutation
- Reverse Transcriptase Inhibitors
- Stavudine
- Zidovudine