Article
Transmission of antiretroviral-drug-resistant HIV-1 variants.
Lancet (London, England) - 28 Aug 1999
Yerly S, Kaiser L, Race E, Bru J P, Clavel F, Perrin L
Abstract excerpt
BACKGROUND: Resistance of HIV-1 to antiretroviral drugs is the main cause of antiretroviral-treatment failure. We assessed the transmission of drug-resistant variants among individuals with primary HIV-1 infection. METHODS: Population-based sequencing of the viral reverse-transcriptase and protease genes derived from plasma viral RNA was done in 82 consecutive individuals with documented primary HIV-1 infection...
Topics
- Adolescent
- Adult
- Anti-HIV Agents
- DNA Mutational Analysis
- Drug Resistance, Multiple
- Female
- Genetic Variation
- Genotype
- HIV Infections
- HIV Protease Inhibitors
- HIV-1
- Humans