Article
Linkage disequilibrium patterns and tagSNP transferability among European populations.
American journal of human genetics - 1 Mar 2005
Mueller Jakob C, Lõhmussaar Elin, Mägi Reedik, Remm Maido, Bettecken Thomas, Lichtner Peter, Biskup Saskia, Illig Thomas, Pfeufer Arne, Luedemann Jan, Schreiber Stefan, Pramstaller Peter, Pichler Irene, Romeo Giovanni, Gaddi Anthony, Testa Alessandra, Wichmann Heinz-Erich, Metspalu Andres, Meitinger Thomas
Abstract excerpt
The pattern of linkage disequilibrium (LD) is critical for association studies, in which disease-causing variants are identified by allelic association with adjacent markers. The aim of this study is to compare the LD patterns in several distinct European populations. We analyzed four genomic regions (in total, 749 kb) containing candidate genes for complex traits. Individuals were genotyped for markers that are...
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