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Article

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice.

Circulation. Heart failure - 1 Jan 2014

Dai Jing, Matsui Takashi, Abel E Dale, Dedhar Shoukat, Gerszten Robert E, Seidman Christine E, Seidman J G, Rosenzweig Anthony

Abstract excerpt

BACKGROUND: Integrin-linked kinase (ILK) is a serine/threonine kinase that has been linked to human and experimental heart failure, but its role in the heart is not fully understood. METHODS AND RESULTS: To define the role of cardiomyocyte ILK, we generated cardiac-specific ILK knockout mice using α-myosin heavy chain-driven Cre expression. Cardiac-specific ILK knockout mice spontaneously developed lethal dilated...

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Source

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Identifiers

PMID: 24319095
DOI: 10.1161/CIRCHEARTFAILURE.113.000649
PMCID: PMC3950354

Genes

ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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